Agailjhara and Gournadi upazilas on the north, Banaripara and Jhalokati Sadar upazila on the south, Babuganj upazila on the east, Kotalipara and Nazirpur upazilas on the west.

Wazirpur thana was turned into an upazila in 1983. It consists of 9 union parishads, 118 mouzas and 117 villages.

Wazirpur Upazila is located in Barisal District. Upazilla(s)/Thana(s) in Barisal are Agailjhara Upazila, Babuganj Upazila, Bakerganj Upazila, Banaripara Upazila, Barisal Sadar Upazila, Gournadi Upazila, Hizla Upazila, Mehendiganj Upazila, Muladi Upazila, Wazirpur Upazila.