Gosairhat upazila on the north, Barisal Sadar upazila on the south, Hizla and Mehendiganj upazilas on the east, Kalkini, Gournadi and Babuganj upazilas on the west.

Muladi thana was established in 1967 and was turned into an upazila in 1983. It consists of 7 union parishads, 98 mouzas and 108 villages.

Muladi Upazila is located in Barisal District. Upazilla(s)/Thana(s) in Barisal are Agailjhara Upazila, Babuganj Upazila, Bakerganj Upazila, Banaripara Upazila, Barisal Sadar Upazila, Gournadi Upazila, Hizla Upazila, Mehendiganj Upazila, Muladi Upazila, Wazirpur Upazila.