Hizla and Muladi upazilas on the north, Barisal Sadar and Bhola Sadar upazilas on the south, Bhola Sadar, Lakshmipur Sadar and Raipur upazilas and east, Muladi and Barisal Sadar upazilas on the west.

Mehendiganj thana was turned into an upazila in 1983. It consists of one municipality, 13 union parishads, 135 mouzas and 161 villages.

Mehendiganj Upazila is located in Barisal District. Upazilla(s)/Thana(s) in Barisal are Agailjhara Upazila, Babuganj Upazila, Bakerganj Upazila, Banaripara Upazila, Barisal Sadar Upazila, Gournadi Upazila, Hizla Upazila, Mehendiganj Upazila, Muladi Upazila, Wazirpur Upazila.